Sweet Syndrome, also known as acute febrile neutrophilic dermatosis, is a rare inflammatory skin disorder with systemic manifestations. Although uncommon, it is critical for primary care physicians to recognize its clinical signs and consider it during differential diagnosis—especially when symptoms rapidly follow medication changes.
This article outlines a documented clinical case and offers a comprehensive review of Sweet Syndrome, including its presentation, diagnostic criteria, treatment, and clinical significance, particularly in relation to medication-induced reactions.
Clinical Case Summary
A 55-year-old female patient with a medical history of hypertension and chronic obstructive pulmonary disease (COPD) presented with erythematous, painful facial and neck lesions accompanied by low-grade fever. She had no known allergies and reported smoking approximately 10 cigarettes daily.Her regular medication regimen included:
Enalapril (6 years)
Inhaled formoterol (2 years)
Due to a deterioration in pulmonary function, her pulmonologist replaced formoterol with a combination of indacaterol and glycopyrronium in capsule inhaler form.
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